Date: 4 months ago   Category: Society

New genetic responsible for the early progressing hair loss is found

Many people face loss of hair, but only the few test it since the childhood. It occurs in the rare hereditary state called by a gipotrikhozny simplex.

Now, at last, researchers could identify the gene responsible for this form of the early progressing hair loss. People with a gipotrikhozny simplex have a normal number of hair after the birth, but they begin to lose them in the early childhood. This loss increases with age.

Though researchers know that this hereditary state, still they identified only the few potential genetic criminals.

One of them - a mutation in a gene of APCDD1 which interferes with the alarm way influencing function of cages and regeneration. Now researchers from university hospital in Germany in cooperation with colleagues from other institutions in Germany and Switzerland have found

one more gene which plays a crucial role in this rare type of a hair loss in Bonn.

indicate their research which results are published in American Journal of Human Genetics that mutations in a gene of LSS operate the mechanisms characterizing a simplex of a gipotrikhoz.

Scientists have analysed genetic information of people from three families which haven't been connected at all. In total eight relatives tested hair loss symptoms.

Looking at their genetic structure, researchers have found out that all of them had mutations in a gene of LSS which usually codes specialized enzyme.

"This gene codes a lanosterol-sintaza - LSS for brevity", - the author of a research professor Regina K. Betts notes. "Enzyme, - she adds, - plays a key role in cholesterol metabolism".

However it has no relation to cholesterol levels in blood. Instead of this LSS influences a metabolic way which defines health of hair follicles.

"Exists an alternative metabolic way for cholesterol which plays an important role in a hair follicle and isn't connected with cholesterol levels in blood", - professor Betts says.

However researchers haven't stopped on this find. They collected samples of fabrics which analyzed. The team could confirm if the person bears a regular gene of LSS, enzyme appears in an endoplasmic retikulum. It is a set of tiny channels in follicle cages.

in case of people with the mutated LSS researchers have found out that enzyme actually spreads out of limits of an endoplasmic retikulum and in cytosol, intracellular liquid.

"The best understanding of causes of illness in the future is able to afford to find new approaches to treatment of a hair loss", - professor Betts says.

Nevertheless, it can take long time until scientists actually find effective treatment of such progressing hair loss.



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