Date: 4 weeks ago   Category: Health

Intestinal bacteria aggravate Parkinson's disease - physicians


Harmful microbes devour drugs and sign to the patient a sentence.

Physicians report that researches of scientists confirmed: intestinal bacteria aggravate Parkinson's disease. Parkinsonism - the progressing neurodegenerative disease caused by a lack of dopamine of a brain. A treatment method - attempt to fill the natural level of dopamine. As dopamine cannot break a hematoencephalic barrier, people are given a levodopa (L-dopu) which saves a brain. Turns into dopamine the human enzyme called by a decarboxylase of aromatic amino acids (AADC). The team took samples a calla from patients with Parkinson's disease and added L-dopu and a karbidopa. At first used a combination of L-dopy in which a part of hydrogen is replaced with a deuterium.

Thus, monitored change of chemicals which are made of L-dopy which came into contact with intestinal microbes of the patient. In biomaterials of people of L-dopa remained as L-dopa. To others - it is transformed. The team found out that the gastrointestinal tract and intestines of people recognized as "house" for bacteria with enzymes which work the same as our own AADC, turning L-dopu into dopamine.

But with an exception: bacterial enzymes are not blocked by karbidopy. Scientists found intestinal bacteria which turn dopamine into chemicals. In other words, with L-finish singing there are positive and negative results depending on what combination of microbes lives in the patient's intestines. Having armed with knowledge of what bacterial enzymes are involved, the team found a blocker which stopped the L-dopy transformation at mice; and in samples of analyses of patients with Parkinson's disease. Having crossed fingers, scientists reported - it works for people.

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