Date: 8 months ago   Category: Health

Geneticists approved a new method of editing human genome


The American officials have approved the first medicine based on the principle of a RNA interference. It is the method allowing "to muffle" work of the genes causing a dangerous disease broadcasts "News of Mail.RU". Means is designed to treat transtiretinovy амилоидоз. This serious hereditary illness which is characterized by damage of a liver.

the Essence of a method consists in the following: from each working gene MRNK which then is delivered from a kernel in cage cytoplasm, to "proteinaceous factories" of a ribosome where according to the instruction of this MRNK protein is synthesized is read out. If you want to break this process, it is required to stop MRNK somewhere halfway to a ribosome.

can Make it if in a cage other RNA capable to form with her a double chain appears. The cage destroys such products at once. Thus, for "muting" of work of a gene just the fragment of this gene needs to enter into the cell of RNA identical on the sequence.

However RNA differs in low stability. The problem managed to be solved, having placed it in fatty nanoparticles. Particles collected in a liver and kidneys. This fact has influenced the choice of target illnesses (so far the method works against illnesses at which the expression of genes in a liver is broken).

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