Date: 10 months ago   Category: Hi-Tech

Death of cells of a brain will stop... spidery poison


Violations of activity of receptors of a brain are the cornerstone of some neurodegenerate diseases of the central nervous system and if these changes manage to be corrected - it will turn out and to overcome the related diseases. The research of the international group of scientists has been directed to it, according to the Neuron edition. And, as it has appeared, spider-krugopryada poison will help with it.

the Research has been aimed at studying of glutamate receptors. The matter is that they that is logical, are activated in an organism thanks to influence of a glutamate due to accession to special proteins and opening in them the ion channel which is passing positively charged ions. Thereof there is an emergence of electric potential which extends to all shoots of neurons. At some diseases of nervous system there is an excessive activation of glutamate receptors. The special danger is born in this case by the receptors which are carrying out calcium, his large number leads to death of cages (as a result of start of process of apoptosis). For this reason to develop substance, the blocking glutamate receptors of calcic channels, quite important task.

during the work scientists, having studied structure of a receptor, have decided to influence him three various connections, first of which represented poison of already mentioned spider-krugopryada (Argiope lobata), and two others - its synthetic analogs. Everyone consists two parts, so-called "head" and "tail". As one of participants of an experiment Alexander Sobolevsky, the graduate of MIPT, and nowadays the employee of Columbia University has said, "These blockers get in a receptor when that opens at action of a glutamate, at the same time they place the positively charged tail in a narrow negatively charged part of an ion channel. The head which is getting stuck in an internal cavity of a receptor doesn't allow to pass the channel to blockers." It has become clear that both toxin of a spider, and synthetic medicines, selectively block those receptors which well pass calcium. At the same time they don't influence receptors in which opening calcium of participation doesn't accept. Thus, medicines on the basis of poison of a spider can influence only the affected receptors and not influence work of healthy sites of neurons of a brain. The obtained information can be used for therapy of such states as a side amyotrophic sclerosis, epilepsy and death of cages at Alzheimer and Parkinson's diseases. This
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